Confocal microscopy revealed that β3-AR was expressed at the basolateral membrane of the A-ICC, identified by the apical expression of H+- ATPase (Roy et al., 2015), the B-ICC expressing the apical Pendrin (Roy et al., 2015), and non-A, non- B-ICC characterized by apical and diffuse vesicular H+-ATPase staining and Pendrin at the luminal side (Roy et al., 2015). This evidence concerns the gene SLC26A4 and intrahepatic cholangiocarcinoma.