An exaggerated pro-inflammatory phase characterises the immune response in sepsis, and a subsequent anti-inflammatory phase is collectively called a "cytokine storm." Pro-inflammatory cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-α), are released in abundance, contributing to systemic inflammation. The gene discussed is IL6; the disease is Sepsis.