RB1 and neoplasm: The synergistic actions of E6 and E7 facilitate the development of HPV-induced cancer by targeting various cellular pathways responsible for regulating cell cycle control through interactions with p53 and pRb, two tumor-suppressing genes [43,46]. Targeting E6 and E7, the biomarkers responsible for driving CC progression through therapeutic approaches, are highly effective in selectively removing the abnormally proliferating malignant cells [43].