ZUP1 and neoplasm: Accordingly, the 100 DUBs identified in humans are generally grouped into seven different families: ubiquitin carboxyl-terminal hydrolases (UCHs), ubiquitin-specific proteases (USPs), ovarian tumour domain proteins (OTUs), Machado-Joseph domain-containing proteases (MJDs), Jab1/Mov34/Mpr1Pad1 N-terminal domain proteases (JAMMs), motif interacting with Ub-containing novel DUB family (MINDYs) and zinc finger with UFM1-specific peptidase domain protein (ZUSFP) (Ronau et al., 2016; Clague et al., 2019).