While most of these subsets contribute to tumor progression, interestingly, there is also a tumor-inhibiting subset called cancer-restraining CAFs (rCAFs) that are Meflin positive and supposedly can soften cancer stroma, however, more research is needed in this matter (Fang et al., 2023; Yamamoto et al., 2023; Zhang et al., 2023). Here, ISLR is linked to cancer.