Peng et al. (2022) reported that extracellular vesicles derived from mesenchymal stromal cells may suppress the Th2 response in allergic rhinitis patients by inhibiting CD86 expression on DCs. Furthermore, numerous investigators have noted diminished levels of CD86 expression in the blood DCs of individuals with multiple sclerosis (MS), suggesting that CD86+ myeloid DCs may have a protective effect in MS (Huang et al., 2001). The gene discussed is CD86; the disease is multiple sclerosis.