Furthermore, the MR Egger method also failed to demonstrate a causal relationship between CD62L− CD86+ Myeloid DCs within DCs (OR = 0.956, 95% CI: 0.897–1.019, p = 0.185) and PD, additionally, numerous analyses did not corroborate a causal relationship between HLA DR+ NK cells within CD3− lymphocytes and CD28 on activated and secreting Tregs in relation to PD, but the IVW results were significant, with no detected pleiotropy or heterogeneity, and the outcomes of all five analytical methods aligned in the same direction, suggesting a positive result overall (Birney, 2022; Figure 2). The gene discussed is CD28; the disease is Parkinson disease.