In conclusion, our results suggest a link between GB accumulation, hypoxia, and an inflammatory-reparative response activated through the HIF/NFκB axis, contributing to infertility in FD patients and indicate new targets for possibly preventing sterility in FD patients by using HIF-1α/NFκB modulators and inflammasome inhibitors (39, 40). Here, NFKB1 is linked to infertility disorder.