In conclusion, our results suggest a link between GB accumulation, hypoxia, and an inflammatory-reparative response activated through the HIF/NFκB axis, contributing to infertility in FD patients and indicate new targets for possibly preventing sterility in FD patients by using HIF-1α/NFκB modulators and inflammasome inhibitors (39, 40). The gene discussed is NFKB1; the disease is Fabry disease.