VEGFA and macular retinal edema: The reasons were as follows (1): compared with the half-life of anti-VEGF drugs, such as ranezumab and comaccept, the intravitreal half-life of aflibercept is usually more than 10 days (21); (2) macular edema caused by retinal laser photocoagulation mostly occurs during photocoagulation or 1 month after treatment (22).