Numerous variables, such as sex, age, race, education level, BMI, smoking status, alcohol consumption, blood uric acid, serum phosphorus, hypertension, diabetes, TC, triglycerides, ALT, AST, PIR, CVD, marital status, ACR, eGFR, SII, NHR, LHR, MHR, and PHR, showed significant differences across SIRI tertiles (all p < 0.05). This evidence concerns the gene GPT and Hypertension.