In contrast, our findings suggest that in the late stages of NAFLD, activated platelets within the steatotic liver release TSP1 and other chemokines (e.g. CXCL1, CXCL2, and CXCL4) to attract immune cells (e.g. monocytes, neutrophils, and T cells) to infiltrate into the liver.18 This evidence concerns the gene THBS1 and metabolic dysfunction-associated steatotic liver disease.