In contrast, our findings suggest that in the late stages of NAFLD, activated platelets within the steatotic liver release TSP1 and other chemokines (e.g. CXCL1, CXCL2, and CXCL4) to attract immune cells (e.g. monocytes, neutrophils, and T cells) to infiltrate into the liver.18 Here, PF4 is linked to metabolic dysfunction-associated steatotic liver disease.