Comparison of a decrease in the level of cells with the CD11b+Ly-6C+ phenotype in the tumor microenvironment in two experimental Karanahan and Karanahan + GcMAF-RF groups and an increase in CD11b+Ly-6C+ peritoneal macrophages in tumor-bearing animals after treatment with GcMAF-RF and the efficacy of synthesis of key immune cell suppressive factors (TGF-β1 and Arg1) indicates the lack of an intrinsic relationship between the CD11b+Ly-6C+ phenotype of cells and their cytokine/suppressor factor synthesizing activity. This evidence concerns the gene ITGAM and neoplasm.