PROM1 and colorectal carcinoma: In CRC mouse models, a whole-CSC vaccine made from CD133+ CSC lysates triggered the increase of NK cell cytotoxicity and secretion of inflammatory chemokines such as IFN-γ, which subsequently inhibits the proliferation of CD133+ and ALDH + cell groups, indicating a reduction in CSC proliferation (Guo et al., 2020).