TNF and type 2 diabetes mellitus: Hyperesistinemia is usually related to T2DM and comes with MetS, where a base for high resistin is related to IR, further predisposing affected patients with a high risk for major adverse cardiac events due to proinflammatory states via cytokines such as tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 [24].