PNLIP and obesity due to melanocortin 4 receptor deficiency: Since excessive fat and carbohydrate consumption causes triglyceride accumulation in the liver and adipose tissues, increasing the risk of developing obesity, hyperlipidemia, and other complications, inhibiting enzymes such as pancreatic lipase, involved in glucolipid metabolism is another mechanism by which obesity can be managed or prevented (Jiang et al., 2021).