Eubacterium sp. cocultured with bladder cancer organoids, which has been proved to retain the histological and genomic features of parental tumors[78], can promote tumor cell proliferation through the ECM1/ERK1/2 phosphorylation/MMP9 pathway, and this microbe is found related to bladder cancer in NMIBC cohort clinically[54]. The gene discussed is MAPK3; the disease is urinary bladder carcinoma.