These include the CASP8 and FADD Like Apoptosis Regulator (CFLAR), an essential activator of the extrinsic pathway of apoptosis (119), and the PPARG Coactivator 1 Alpha (PPARGC1A), a master regulator of mitochondrial biogenesis and antioxidant defense (120), with decreased protein levels in the placenta in PE, especially in cases associated with IUGR (121). The gene discussed is CASP8; the disease is fetal growth restriction.