Finally, we could identify gene hits from the GO category of the ‘blood vessel endothelial cell migration’ pathway: these included the already-found ATP2B4 and COX2 genes, but also Neurofibromin1 (NF1), a gene mutated in neurofibromatosis 1 patients, who have a higher risk of developing PE and IUGR (131). The gene discussed is NF1; the disease is fetal growth restriction.