When it comes to treating hepatocellular carcinoma, Astragalus membranaceus Polysaccharide could enhance the expression of M1 macrophage biomarkers (such as iNOS, IL-1β, and TNF-α) and M1 macrophage proportions, as well as could reduce the expression of M2 macrophage biomarkers (including IL-10, Arg-1) and M2 macrophage proportions in the tumor-associated macrophages (TAMs)/MHCC97H cells and TAMs/Huh7 cells co-cultured models. The gene discussed is TNF; the disease is neoplasm.