Moreover, hum-2-VHH-LC was able to induce bystander killing similar to R11-scFV-1, which directly indicates the capacity of hum-VHH-2-LC to target tumors expressing heterogeneous levels of ROR1 and indirectly suggests that hum-VHH-2-LC can promote infiltration of immune cells into tumors and endogenous and durable tumor specific immunity. This evidence concerns the gene ROR1 and neoplasm.