NDUFB6 and lobular neoplasia: Taken together, it is not hard to notice that new agents modulating oxidative stress and mitochondrial metabolism might have a potent therapeutic role in the treatment of LN; Complex I (CI, NADH: ubiquinone oxidoreductase) refers to mitochondrial oxidative phosphorylation (OxPhos) enzyme complex consisting of 45 subunits, and its dysfunction would generally impair energy production and affect various organs including kidneys (47).