identified that constitutive p40 is mainly expressed by CD8α−CD11b_CD11c+ lamina propria DCs in the distal ileum and elevated bacterial load in the terminal ileum fosters Nuclear Factor kappa-B (NF-κB) expression of the p40 gene; this excessive pool of p40 protein leads to high levels of IL-23, which contributes to the development of IBD (15). Here, IL23A is linked to inflammatory bowel disease.