They can be produced by leukocytes, fibroblasts, and tumor cells (12), playing a role in cancer development with interferons (IFN), interleukins (IL), colony-stimulating factors (CSF), tumor necrosis factors (TNF), transforming growth factors (TGF), and a wide range of chemokines (13), controlling different stages of cancer, such as apoptosis, angiogenesis, proliferation, invasion, metastasis, and currently the development of chemoresistance (3). This evidence concerns the gene CSF2 and cancer.