TNF and neoplasm: They can be produced by leukocytes, fibroblasts, and tumor cells (12), playing a role in cancer development with interferons (IFN), interleukins (IL), colony-stimulating factors (CSF), tumor necrosis factors (TNF), transforming growth factors (TGF), and a wide range of chemokines (13), controlling different stages of cancer, such as apoptosis, angiogenesis, proliferation, invasion, metastasis, and currently the development of chemoresistance (3).