KLF4 and digestive system neoplasm: In resistance to cisplatin in GC, an H. pylori infection produces high levels of inflammatory cytokines such as TNF-α (78) and induces miR-135b-5p production by suppressing KLF4 (Kruppel-like factor 4) is a transcription factor that regulates proliferation, apoptosis, inflammation, and tumorigenesis, acting as a tumor suppressor in gastrointestinal tumors (79).