A study conducted in South Africa grouping HIV-infected individuals based on HIV viral load and CD4+ T cell counts found that, regardless of the presence of viremia or immunosuppression, the mortality rate of COVID-19 patients with HIV positivity was significantly higher than that of HIV-negative patients, with viral load ≥1,000 copies/mL or CD4+ T cell counts <500/μL associated with the highest risk of death (32). This evidence concerns the gene CD4 and COVID-19.