Importantly, when we analyzed separately the effect of DIAPH3 expression on survival in MGMT-methylated and unmethylated glioblastomas, we observed a striking difference between high and low expression of DIAPH3 within the MGMT-methylated group (P=0.018, log-rank test; HR=0.369, 95% CI: 0.156-0.871, P=0.023, Cox proportional hazards analysis; Figure 3A), while the effect of DIAPH3 expression level was not significant within the MGMT-unmethylated group (P=0.086, log-rank test; HR=0.579, 95% CI: 0.307-1.091, P=0.091, Cox proportional hazards analysis; Figure 3B). Here, MGMT is linked to glioblastoma.