The cyclic adenosine monophosphate (cAMP) response element‐binding protein (CREB) is an essential transcription factor involved in numerous cellular activities, including synaptic plasticity, neuroprotection, and memory consolidation.[48] Post‐mortem analyses of AD‐affected brains have showcased reduced CREB phosphorylation, highlighting the disrupted functional landscape of the disease environment.[49] PQQ amplifies the transcriptional activity of CREB1 in AD, raising the expression of the anti‐inflammatory genes Cnr1 and Cx3cr1. Here, CX3CR1 is linked to Alzheimer disease.