LRIG1 and neoplasm: Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a known tumor suppressor gene [28], and it has been proposed as a prognostic indicator for various malignancies, including prostate cancer [29], head-and-neck cancer [30], cutaneous squamous cell carcinoma [31], breast carcinoma [32], and uterine cervical carcinoma [33].