In addition, circRYK could enhance the stability of VLDLR mRNA via the RNA-binding protein HuR.<h4>Conclusion</h4>Our findings show that TGF-β promotes epithelial-mesenchymal transition and GSC maintenance in GBM through the circRYK-VLDLR axis, which may provide a new therapeutic target for the treatment of GBM. This evidence concerns the gene TGFB1 and glioblastoma.