Interestingly, we and other two groups have identified that FAM83D could negatively regulate the protein level of FBXW7, a well-recognized tumor suppressor, and thereby accelerating the carcinogenesis in breast, hepatic and colorectal cancers, suggesting that FAM83D-mediated FBXW7 downregulation was an important mechanism underlying the oncogenic action of FAM83D [19, 22, 42]. The gene discussed is SACK1D; the disease is colorectal cancer.