Thus, defining the molecular landscape in BC and unraveling novel contributors to BC initiation and progression is of great significance for discovering effective drug targets to improve treatments and prognosis for the BC patients. FAM83D is the newly identified member of FAM83 (Family with sequence similarity 83) protein family which has 8 members consisting of FAM83A, FAM83B, FAM83C, FAM83D, FAM83E, FAM83F and FAM83G. Here, SACK1E is linked to breast cancer.