FBXW7 and cancer: Growing number of studies have shown that multiple mechanisms contributed to the deficiency of FBXW7 in cancers including post-transcriptional regulation at protein level such as phosphorylation-induced mislocalization or loss of dimerization thereby encouraging self-ubiquitination, and cis- or trans-ubiquitination triggered by imbalanced specific E3 ligases and deubiquitinating enzymes followed by accelerated degradation.