CD8A and neoplasm: This suppression was characterized by reduced levels of CD8 + T-cells, B-cells, two T-cell subsets (Th1-cells and Th2-cells), tumor-infiltrating lymphocytes (TIL), T-cell co-stimulation, antigen-presenting cell (APC) co-stimulation, as well as elevated levels of regulatory T-cells (Treg) and APC co-inhibition (Fig. 10c and Supplementary file 4).