Inositol 1,4,5-triphosphate and DAG subsequently regulate various processes that affect gene expression, cell growth, and differentiation.18 Evidence indicates that PLCE1 is tightly related to the clinical staging and survival of CRC patients.19 Importantly, PLCE1 has been indicated to exert an inhibitory effect on the incidence of CRC. Here, PLCE1 is linked to colorectal carcinoma.