Notably, the mRNA levels of 6 dDEGs were prominently associated with READ patients’ prognosis, including phospholipase C epsilon 1 (PLCE1), cyclooxygenase 1 (PTGS1), aminomethyltransferase (AMT), ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (ST8SIA1), ST3GAL5, and GBA2. The gene discussed is ST8SIA1; the disease is reading.