ST3GAL5 and rectal carcinoma: ST3GAL5 has been verified to be implicated in multiple malignancies, such as bladder cancer and hepatocellular carcinoma.24,25 Previous evidence has suggested that ST3GAL5 is overexpressed in rectal carcinoma samples compared to normal samples.26 On the contrary, this study revealed that ST3GAL5 was underexpressed in CRC samples and that overexpressing ST3GAL5 led to reduced aggressiveness of CRC cells in vitro.