To determine the specific roles of GBA2 and ST3GAL5 in affecting the biological behaviors of CRC cells, we separately overexpressed GBA2 and ST3GAL5 in 2 CRC cell lines (LoVo and SW620) using their corresponding overexpression vectors (GBA2-OE or ST3GAL5-OE). This evidence concerns the gene GBA2 and colorectal carcinoma.