Intriguingly, evidence has demonstrated ST8SIA1 upregulation in CRC tissues and that upregulating ST8SIA1 could attenuate miR-33a/let-7e-mediated suppressive effects on cell proliferation and chemoresistance in CRC.23 Consistent with this, our experimental data depicted that the ST8SIA1 level in CRC cell lines was much higher than in the nontumor cell line. This evidence concerns the gene ST8SIA1 and colorectal carcinoma.