Kawamoto and collaborators as well as other investigators revealed nestin amounts in tumor cells correlate with nerve invasion in PC.29 Furthermore, nestin is strongly immunoreactive in nerve fibers of both PDAC and chronic pancreatitis specimens, likely indicating neural remodeling that is critical for the generation of pancreatic neuropathy.30 The TERT gene at chromosome 5p15.33 is translated into the catalytic subunit of telomerase reverse transcriptase that represents a constituent of the protein/RNA complex maintaining telomere ends. This evidence concerns the gene TERT and chronic pancreatitis.