The critical role of the NF-κB pathway in PC progression, via EMT promotion and lymphovascular and neural invasion, was also demonstrated.21 In the in vitro experiment of mouse dorsal root ganglion in prostatic cancer, nerves injured by tumor invasion promote the release of CCL2, generate an inflammatory reaction of nerve restoration, and induce CCR2 cancer cells to migrate to these nerves. This evidence concerns the gene NFKB1 and pachyonychia congenita.