As a result of this current study, in the high-dose agmatine treatment group, the proinflammatory cytokines TNF-α, IL-1, and TGF-β levels were found to be low, and the antioxidant cytokines SOD and MDA levels were found to be high, which is a pioneer finding of positive agmatine efficacy on experimental AP model. The gene discussed is TGFB1; the disease is alkaline phosphatase measurement.