In addition to clinical conditions including sepsis, trauma, and venous thromboembolism,3 histones and NETs were investigated in the experimental models of inflammatory bowel diseases (IBDs).9-11 Neutrophile extracellular traps were investigated in mucosal biopsies of a limited number of IBD patients.10-14 Currently, there is a lack of data about the role of HH4 and other NETs in the clinical and laboratory evaluation of UC. This evidence concerns the gene PROK2 and inflammatory bowel disease.