Antiangiogenic therapy is a new and effective approach in the treatment of angiogenesis-related diseases such as cancer.19 Inhibitors affecting the function of kinases in biological research are valuable for the treatment of kinase-related diseases such as different cancers.29,42 Among mitotic regulatory kinases, the evolutionarily conserved family of serine/threonine kinases termed “Aurora kinases” emerged as an extremely attractive target for anticancer drug discovery. Here, MARK2 is linked to cancer.