It is overexpressed in numerous malignancies, including breast, colorectal, and liver carcinoma.49,50 Overexpression of VEGF and its receptors provide the survival advantage and regulation of tumor growth.20 In the study, time/dose depended Danusertib in CFPAC-1 cells was shown that VEGF gene expression was decreased 0.5-fold at 24th hour and 0.3-fold at 48th hour. This evidence concerns the gene VEGFA and neoplasm.