Notably, BAG5 has been reported to act as a co-chaperone by regulating HSP70-mediated protein folding in Parkinson’s disease (PD) and HSPA8-mediated proteostasis in dilated cardiomyopathy (De Snoo et al, 2019; Hakui et al, 2022; Kalia et al, 2004). This evidence concerns the gene BAG5 and Parkinson disease.