APOC3 and hyperlipidemia: However the only genes reported to be associated with clinical hyperlipidaemia, as indicated by taking lipid lowering medication or having a hyperlipidaemia diagnosis recorded, were LDLR, PCSK9 and APOC3. For the AstraZeneca study, all gene-wise and variant-wise associations with 17,361 binary and 1419 quantitative phenotypes are reported on the AstraZeneca PheWAS Portal at https://azphewas.com/ [2].