STUB1 and acute kidney injury: CHIP was associated with a 20% greater risk of AKI in a meta-analysis of these two cohorts (HR = 1.20; 95% CI = 1.03–1.39), leading to an overall risk of 26% after meta-analysis with the UKB (HR = 1.26, 95% CI = 1.19–1.34; Fig. 1a).