The risk for AKI associated with CHIP was enhanced in individuals with mutations in genes other than DNMT3A (Fig. 1b; HR = 1.54, 95% CI = 1.41–1.68 for any AKI and HR = 2.18, 95% CI = 1.51–3.15 for AKI-D, P < 0.0001). Here, DNMT3A is linked to acute kidney injury.