Consistent with what was observed in the UKB, the point estimate of the magnitude of relative risk for AKI was higher for individuals with non-DNMT3A-CHIP (Fig. 1b; meta-analyzed HR = 1.28, 95% CI = 1.06–1.55) and across many of the top individual genes in this subgroup (Extended Data Fig. 2), while DNMT3A-CHIP was not associated with AKI. This evidence concerns the gene STUB1 and acute kidney injury.