Among individuals with AKI, non-DNMT3A-CHIP and large CHIP clones (VAF ≥ 10%) were more than twice as common among individuals with a nonresolving AKI pattern compared to those with resolving AKI (Fig. 2a), including after adjusting for age and other relevant covariates (Fig. 2b). The gene discussed is DNMT3A; the disease is acute kidney injury.