Finally, we show that AKI severity is more pronounced and AKI recovery is impaired in mouse models with Tet2-CHIP and Jak2V617F-CHIP across both ischemia–reperfusion injury (IRI) and unilateral ureteral obstruction (UUO) AKI models, with risk mediated by an aberrant inflammatory response in CHIP-mutant renal macrophages. The gene discussed is STUB1; the disease is Ureteral obstruction.