HCK and mantle cell lymphoma: In contrast, KIN-8194 potently reduced the growth of all studied MCL cell lines (GI50: 7–25 nM), with the exception of Z-138 (Fig. 1A, B), an atypical MCL cell line with blastoid transformation and the only tested MCL cell line that lacks HCK expression (Fig. 1C) [21, 25].