Noteworthy, KIN-8194 and ibrutinib treatment did not reduce integrin-α4, -β1 or -β2 levels on the cell membrane and the observed loss of adhesion of JeKo-1, Maver-1, Granta-519, and primary MCL cells could be overcome by stimulation of PKC by PMA (Supplementary Fig. 7). The gene discussed is PRRT2; the disease is mantle cell lymphoma.