MTOR and cancer: The mammalian target of rapamycin (mTOR), a serine/threonine protein kinase,218 is a key target in cancer research due to its involvement in the PI3K/AKT/mTOR signaling pathway, which is frequently activated in human cancers and is often associated with therapeutic resistance.219 Both mTORC1 and mTORC2 have been implicated in ferroptosis in human cancers.