Notably, EMT could be induced by histone deacetylase inhibitor with increased intracellular iron accumulation and reduced expression of the iron export protein ferroportin, thereby enhancing vulnerability to ferroptosis.249 Erlotinib-tolerant persistent cancer cells also maintain mesenchymal characteristics with increased glutaminolysis induced by histone lysine demethylase 5 A (KDM5A) mediated mitochondrial pyruvate carrier 1 (MPC1) inhibition.250 Consequently, these cells become susceptible to ferroptosis. Here, MPC1 is linked to cancer.