TP53 and breast carcinoma: Moreover, the TP53 single-nucleotide polymorphism P47S found in many people of pre-menopausal African-American women has an increased risk of breast cancer.152,154 Mechanistically, p53P47S is defective in promoting ferroptosis and repressing tumor development through increasing the cellular levels of CoA and GSH.154 These findings indicate that ferroptosis is at least partly responsible for TP53-mediated tumor suppression.