Tumor suppressors such as p53, BRCA1-associated protein 1 (BAP1), fumarate hydratase (FH), Kelch-like ECH-associated protein 1 (KEAP1), and the epigenetic regulator MLL4 have been shown to exert their tumor-suppressive functions, at least partially, by inducing ferroptosis in tumor cells. This evidence concerns the gene KEAP1 and neoplasm.