CD8A and neoplasm: A growing body of evidence has demonstrated that combining ICIs and ferroptosis-inducing agents synergistically inhibits tumor growth in vitro and vivo.19,309,382 For example, the combined treatment of GPX4 inhibitors and anti-PD-1 blockade significantly suppressed tumor growth and induced a pronounced immune response with increased proportions of activated CD8+ T cells in TNBC tumor-bearing immunocompetent mice.382 IL-1β sustains Fe-S cluster maintenance to repress iron accumulation and ferroptosis.