GPX4 and familial pancreatic carcinoma: Inhibiting ferroptosis through the administration of liproxstatin-1 reduces the formation of spontaneous pancreatic cancer and reverses the promotion of PDAC development by high-iron diets or GPX4 depletion.319 The initiation of ferroptosis-driven pancreatic cancer may be associated with macrophage infiltration and activation, which is mediated by the release of 8-OHG caused by ferroptotic damage and subsequent activation of the STING-dependent DNA sensor pathway in macrophages.319