Mechanistically, SOCS2 transfers the attached ubiquitin to SLC7A11 and promotes K48-linked polyubiquitination degradation of SLC7A11.391 Conversely, stanniocalcin 2 (STC2) activate PRMT5, leading to upregulation of SLC7A11 and resistance to ferroptosis, thus playing a role in ESCC radioresistance.390 Other mechanisms that inhibit ferroptosis also contribute to radioresistance. Here, SLC7A11 is linked to esophageal squamous cell carcinoma.