Zalcitabine, also known as 2’, 3’-dideoxycytidine, is used for the treatment of patients infected with the human immunodeficiency virus (HIV) by targeting mitochondrial DNA polymerase gamma (POLG).448 Zalcitabine induces autophagy-mediated ferroptosis in pancreatic cancer cells by activating mitochondrial DNA stress and the STING1/TMEM173-dependent DNA sensing pathway.449. This evidence concerns the gene STING1 and familial pancreatic carcinoma.