GPX4 and neoplasm: However, it is worth mentioning that non-selective deletion of GPX4 in Tregs not only elicits anti-tumor immunity but also detrimental autoimmunity, such as significant inflammation in the colon.364 Therefore, future studies should further determine how to selectively target tumor-infiltrating Tregs without affecting Tregs in healthy tissues when inducing ferroptosis to avoid systemic loss of immune tolerance.