As expected, the combination of class I FINs that inhibit SLC7A11 or class II or III FINs that inhibit or deplete GPX4 with IR demonstrated synergistic effects in inducing lipid peroxidation and ferroptosis.372 Moreover, suppressors of cytokine signaling 2 (SOCS2) were screened out as a potential biomarker predicting radiosensitivity of HCC. This evidence concerns the gene SOCS2 and hepatocellular carcinoma.