For example, mutated KRAS protein derived from ferroptotic PDAC cells is packaged into exosomes, which are then engulfed by adjacent macrophages, promoting their subsequent polarization into an M2 tumor-promoting state.321 Administration of ferrostatin-1 can inhibit the tumor-promoting growth arising from peripheral blood mononuclear cell-derived macrophages (PBMCMs) in immunodeficient mice.321 However, the impact of ferroptosis inhibition on PDAC tumor progression has not been investigated in immunocompetent mice. Here, KRAS is linked to neoplasm.