TP53 and cancer: Consistently, cell cycle promoter GINS4 suppresses ferroptosis in LUAD via inhibiting p53 acetylation and promoting SLC7A11 expression.251 MDM2/MDMX, MEX3A, and ZNF498 inhibit p53’s transcriptional activity through post-translational modifications in different subtype cancer cells, thereby suppressing p53-mediated ferroptosis.252–254 However, p53 can also inhibit ferroptosis in a context-dependent manner.