β-Elemene (β-ELE), derived from Curcuma wenyujin, is widely used to treat NSCLC in clinical settings in China.450 β-ELE binds to transcription factor (TFEB), which is the key regulator of lysosome biogenesis, and notably activates TFEB-mediated lysosome degradation of GPX4, thus inducing NSCLC ferroptosis and resulting tumor suppression.451. The gene discussed is TFEB; the disease is neoplasm.