Cyclin-dependent kinase 7 (CDK7) independently promotes nuclear YAP phosphorylation at the S127 and S397 sites, inducing downstream LDHD protein expression and D-lactate-induced ferroptosis resistance in esophageal squamous cell carcinoma (ESCC).261 Glutamine-fructose-6-phosphate transaminase (GFPT1) maintains YAP stability through o-GlcNAcylation, countering Hippo pathway suppression. This evidence concerns the gene GFPT1 and esophageal squamous cell carcinoma.