The mammalian target of rapamycin (mTOR), a serine/threonine protein kinase,218 is a key target in cancer research due to its involvement in the PI3K/AKT/mTOR signaling pathway, which is frequently activated in human cancers and is often associated with therapeutic resistance.219 Both mTORC1 and mTORC2 have been implicated in ferroptosis in human cancers. The gene discussed is AKT1; the disease is cancer.