FH and renal carcinoma: FH is an enzyme involved in the tricarboxylic acid (TCA) cycle, which has been confirmed as a bona fide tumor suppressor in renal cancer.157 Genetic mutation of FH has been detected in both benign and malignant renal cancer lesions.157–159 Notably, renal cancer cells with FH mutations display resistance to ferroptosis and maintain their viability and ability to proliferate even when deprived of cystine.