This study discovered that (1) ZNF692 promotes the glycolysis and malignant development of HepG2 cells; (2) ZNF692 and ALDOA promote HCC growth in nude mice; (3) ZNF692 catalyzes the transcription of KAT5; (4) KAT5 acetylates ALDOA and promotes ALDOA protein expression; (5) ZNF692 exerts oncogenic effects in HepG2 cells via the KAT5/ALDOA axis. This evidence concerns the gene ALDOA and hepatocellular carcinoma.