CDH5 and cancer: However, it is crucial to recognize that ECs within tumors can adopt inflamed phenotypes, contributing to tissue inflammation and cancer aggressiveness by: (i) producing proinflammatory factors such as IL6 that induce macrophage polarization [72]; (ii) reduced expression of VE-cadherin and CD31 alongside increased expression of adhesion molecules, that facilitate leukocyte extravasation and metastasis [73].