The mean largest diameter of the primary tumour was 33 mm for the entire population and there were N = 14 (18.9%) patients with T1C tumours (N = 5 TOP2A + and N = 9 TOP2A-), and N = 57 (77.0%) patients with T2-3 tumours (N = 34 TOP2A + and N = 23 TOP2A-). This evidence concerns the gene TOP2A and neoplasm.