IL6 and obesity due to melanocortin 4 receptor deficiency: Research by Hotamisligil and colleagues suggests that obesity is a systemic state of chronic low-grade inflammation, with the resulting inflammatory response believed to be a key risk factor for obesity-related complications [9].This chronic low-grade inflammatory state associated with obesity is closely linked to the release and induction of numerous related inflammatory factors [4].TNF-α and IL-6 are inflammatory cytokines associated with obesity, particularly abdominal obesity [49].