Reports have indicated the detection of high levels of IL-6, TNF-α, and NF-κB in the reproductive tissue of SD obese rats and C57BL/6 obese mice fed a high-fat diet, along with reduced testosterone levels, thereby affecting spermatogenesis [31, 32].Therefore, we hypothesize that obesity-induced chronic inflammation is indeed related to damage in the male reproductive system. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.