GP6 and stroke disorder: GPVI is strongly activated by atherosclerotic plaque due to the high concentration of collagen I and III.8 Atherosclerotic plaque rupture is a key driver of diseases such as stroke and myocardial infarction9,10 and exposes sub-endothelial collagen, which activates platelets specifically through GPVI.8,11,12 The specific involvement of GPVI in platelet activation by plaque but not normal haemostatic function has led to it being an attractive target for treating arterial thrombosis.13,14