Decreases ASM mass by depletion of eosinophils in the bronchial lamina propria [192]Reduces eosinophil counts in the blood and sputum [125, 126]Reduces AHR to mannitol [193]Improved ventilation assessed by 129Xe MRI in patients with uncontrolled asthma and in those with significant  mucus plugging [224]. The gene discussed is AHR; the disease is asthma.