Another T1D-associated region on chromosome 12 is the SH2B3 locus, with rs597808 being the most significant variant (OR = 1.27, P = 4.82 × 10−11) and in high LD (r2 > 0.96) with previously identified variants in this region (rs653178 [28] and rs7310615 [29]). This evidence concerns the gene SH2B3 and type 1 diabetes mellitus.