In the EUR ancestry group, the HLA-DRB1*08:01-DQA1*04:01-DQB1*04:02 haplotype (differing only at the second field of HLA-DRB1*08) was associated with increased risk for T1D (OR = 1.81, P = 5.5 × 10−5). Here, HLA-DRB1 is linked to type 1 diabetes mellitus.