PTPN22 and type 1 diabetes mellitus: Seven known T1D-associated loci were identified with genome-wide significance (P < 5.0 × 10−8): 1p13.2 (PTPN22), 6p21.32 (HLA-DQA1), 10p15.1 (IL2RA), 10q23.31 (RNLS), 11p15.5 (INS), 12q13.2 (IKZF4-RPS26-ERBB3), and 12q24.12 (SH2B3) (Table 1; Supplementary Fig. 2A and B, Supplementary Fig. 3A–F).