In the NRP1 locus, the same variant associated with T1D risk and with T1D age at onset only reached genome-wide significance in the meta-analysis of AFR and AMR ancestry subjects (rs722988, HRAFR_AMR = 1.41, PAFR_AMR = 2.41 × 10−8) (Supplementary Fig. 4B). The gene discussed is NRP1; the disease is type 1 diabetes mellitus.