The results in the orthotopic animal model of liver cancer showed that ultrasound combined with Schisandin A contrast microbubbles could significantly reduce the tumor volume, reduce the level of inflammatory factors in the animal body, and effectively inhibit the HIF-1α/VEGF/VEGFR pathway and PI3K-AKT-mTOR signaling pathway, which was a potential important therapeutic mechanism. The gene discussed is VEGFA; the disease is liver cancer.