Kinoshita et al. demonstrated that miRNA-218 modulated the focal adhesion pathway, thereby impeding tumor cell invasion and metastasis.9 The liver, which serves as the primary blood-borne drainage site for related organs, such as the portal vein system, colon, and pancreas, is crucial for distant metastasis in patients with PDAC.17 To gain a deeper understanding of the correlation between LAMA3 and liver metastasis in PDAC, we examined independent risk factors associated with liver metastasis. This evidence concerns the gene LAMA3 and neoplasm.