WSB1 is able to target HIPK2 (54), VHL (55), RhoGDI2 (56) and ATM (57) for ubiquitination and degradation in caner development and progression and build K27- and K29-linked ubiquitin chains on LRRK2 for protein aggregation in the pathogenesis of Parkinson's disease (58), suggesting a broad substrate specificity of WSB1. This evidence concerns the gene ARHGDIB and Parkinson disease.