We found that CIH exposure reduced the expression of p-LKB1, p-AMPK and Nrf2 in vitro and in vivo, suggesting that CIH exposure may aggravate oxidative stress and promote glycolipid metabolism disorders by inhibiting LKB1/AMPK/Nrf2 signaling pathway, and further aggravate the cardiac function impairment of DCM. This evidence concerns the gene STK11 and familial dilated cardiomyopathy.