In a mouse tumor model, IL-1B may promote thrombosis through the regulation of neutrophil colony-stimulating factor [26].NOD-like Receptor Thermal Protein domain Associated Protein 3 (NLRP3) activated under hypoxia NLRP3 is activated under hypoxia, which promotes IL-1B expression, contributes to venous thrombosis, and thus induces platelet activation [27]. The gene discussed is IL1B; the disease is neoplasm.